Lifeboat Foundation News Blog Biotechmedical Biology Diagrams The main aim of the present systematic review was to summarize the most frequently used telomerase regulators with an impact on aging and cancer that are referred to in in vitro and in vivo studies. For this purpose, a systematic review of the available literature on telomerase regulators referred to in articles from PubMed and Scopus libraries published from 2002 to 2021 and in accordance
Background: Although telomerase has potential for age-related disease intervention, the overexpression of telomerase in about 90% of cancers, and in HIV virus reservoirs, cautions against se in anti-aging telomerase therapeutics. While multiple reviews document the canonical function of telomerase for maintenance of telomeres, as well as an increasing numbers of reviews that reveal new non FraGKiadaKi et al: TeloMeraSe2 acTiVaTion and inHiBiTion with the enzyme telomerase, which is expressed in specific cell types (2). Telomerase is a reverse transcriptase, responsible for the
A Review of Telomere Attrition in Cancer and Aging: Current Molecular ... Biology Diagrams
Aging Cell 17, e12838 (2018). Nagpal, N. et al. Small-molecule PAPD5 inhibitors restore telomerase activity in patient stem cells. Cell Stem Cell 26, 896-909.e8 (2020). Abstract. The main aim of the present systematic review was to summarize the most frequently used telomerase regulators with an impact on aging and cancer that are referred to in in vitro and in vivo studies. For this purpose, a systematic review of the available literature on telomerase regulators referred to in articles from PubMed and Scopus libraries published from 2002 to 2021 and in Telomerase and Aging: Insight from Age-Related Diseases and Progeroid Syndromes. Telomerase plays a crucial role in the relationship between telomeres and aging Telomerase inhibition: Proinflammatory cytokines such as IL-6 and TNF-ฮฑ can inhibit telomerase activity, particularly the catalytic subunit TERT.
Some telomerase inhibitors, a class of chemotherapeutics, act on certain cancer types, sparing neighboring cells. Optimal Genetic Approaches for Age-Related Diseases and Premature Aging Disorders. Telomerase gene therapy delivers TERT effectively into a gene and has been shown to slow cell aging and increase lifespan without increasing The main aim of the present systematic review was to summarize the most frequently used telomerase regulators with an impact on aging and cancer that are referred to in in vitro and in vivo studies.
Distinct roles of telomerase activity in age Biology Diagrams
The recognition of this interplay has promoted the development of novel therapeutic approaches centered around telomerase inhibition. This review provides a comprehensive overview of the field, emphasizing recent progress in knowledge and the implications in understanding of cancer biology.
