Proteasome and protein degradation Biology Diagrams Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and cyclins and thereby targets them for

Proteasome and protein degradation Biology Diagrams

It has recently become clear that several other proteins are degraded at specific points in mitosis. This review (which is part of the Chromosome Segregation and Aneuploidy series) focuses on how specific proteins are selected for proteolysis at defined points in mitosis and how this contributes to the proper coordination of chromosome

Protein degradation resources โ€“ Bristol Myers Squibb Biology Diagrams

Dynamics of protein synthesis and degradation through the cell cycle Biology Diagrams

Since the description of mitosis by Flemming in 1882, studies on somatic cell division have focused on the equal partition of cellular materials, in particular that of the chromosomes and mitotic apparatus, between cell daughters (1, 2).We now report that many mitotic divisions are unequal with respect to pericentrosomal proteins targeted for proteasomal degradation.

Figure 1 from Degradation of an Old Human Protein Biology Diagrams

Mouery et al. utilize deep, quantitative proteomics to reveal a PLK1-regulated program of G2/M protein degradation. They show that the PKA-anchoring protein AKAP2 is degraded in a manner dependent on PLK1 and the E3 ubiquitin ligase SCFฮฒTrCP and that disruption of AKAP2 degradation results in defects of the mitotic cytoskeleton.

(PDF) Cellular proteostasis: Degradation of misfolded proteins by lysosomes Biology Diagrams

The Consequences of Chromosome Segregation Errors in Mitosis and ... Biology Diagrams

The half-lives of proteins within cells vary widely, from minutes to several days, and differential rates of protein degradation are an important aspect of cell regulation. Many rapidly degraded proteins function as regulatory molecules, such as transcription factors. The entry of all eukaryotic cells into mitosis is controlled in part by

Cellular pathways of protein degradation remove misfolded proteins ... Biology Diagrams

During mitosis, known degradative functions are mainly restricted to UPS, specialized in ubiquitin-triggered protein degradation and presumably faster than lysosome-dependent degradation. Lysosomes are acidic cytosolic vesicles responsible to enzymatically degrade all types of biological material.

Figure 1 from Opportunities and challenges of protein Biology Diagrams