Systemic DNA damage accumulation under in vivo tumor growth can be Biology Diagrams Here we synthesize accumulating evidence that DNA damage affects most, if not all, aspects of the ageing phenotype, making it a potentially unifying cause of ageing. Targeting DNA damage and its mechanistic links with the ageing phenotype will provide a logical rationale for developing unified interventions to counteract age-related dysfunction
Accumulation of DNA damage has been observed in human and mouse HSCs as well as in muscle, intestinal, mesenchymal, neural, skin and germ stem cells 72.
DNA damage and its links to neuronal aging and degeneration Biology Diagrams
It should be noted that these techniques mainly provide snapshots of DNA damage accumulation and not direct assessments of DNA repair dynamics at specific sites. In the future, combining insights from these methods with those that allow for direct monitoring of DNA repair should reveal how DNA damage contributes to the decline in neuronal The accumulation of these DNA damage can be particularly deleterious in postmitotic cells such as neurons, which are not self-renewed through cell proliferation (Coppede and Migliore 2009). It is believed that DNA damage can promote the age-associated neurodegenerative process such as Alzheimer's disease
Overall, these lines of evidence suggest DNA damage accumulation in aged skin stem cells and raises the question of how these stem cells address this burden. HFSCs, as many of the tissue specific stem cells, are more resistant to DNA damage induced apoptosis compared to more differentiated cells (Solanas et al. 2017; Gutierrez-Martinez et al. 2018
DNA damage in aging, the stem cell perspective Biology Diagrams
Recent studies have highlighted the role of DNA damage, particularly DNA double-strand breaks (DSBs), in the progression of neuronal loss in a broad spectrum of neurodegenerative diseases. In the present study, we tested the hypothesis that accumulation of DNA DSB plays an important role in AD pathogenesis.
